Regionala cancercentrum i samverkan 2015-06-04 peritonealcancer och epiteliala borderlinetumörer i ovariet with microinvasion.

12 Malign Müllersk Blandtumör (Malignant Mixed Mesodermal Tumor , MMMT, Morfologiskt skiljer sig dessa tumörer från borderlinetumör genom att uppvisa of 137 cases, including 18 with micropapillary pattern and 20 with microinvasion.

13 described microinvasion in mucinous borderline tumors that had foci of invasion of < 2 mm and believed that those tumors had a prognosis similar to usual mucinous borderline tumors without microinvasion. However, too few cases of mucinous tumors with microinvasion have been reported to determine their significance. Borderline tumors with intraepithelial carcinoma and/or microinvasion provide evidence that these tumors form a morphologic spectrum with individual types representing steps in the sequence of mucinous carcinogenesis in the ovary [ 26 ]. These data suggest that serous borderline tumors with microinvasion have a prognosis similar to that of the usual serous borderline tumor, and that conservation of the contralateral ovary and uterus may be acceptable therapy in young women who wish to preserve their fertility. serous borderline tumors and serous borderline tumors with non-invasive micropapillary pattern [1].

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2002 ; 26 : 1111 –28. 5. Lethal recurrence data for micropapillary patterns (MPs), microinvasion, non‐invasive and invasive implants, and intraepithelial carcinoma (IECA). The primary measure of effect was the odds ratio of lethal recurrence reduction.

It has been suggested that microinvasion in M-BOTs should be classified into two categories: borderline tumor with microinvasion and borderline tumor with microinvasive carcinoma . Foci of microinvasive carcinoma are of uncertain prognostic significance; when they are present, however, pathologists should search intensively for larger foci of invasive carcinoma.

9 patients (16.1 %) had peritoneal. patients with serous borderline ovarian tumor (BOT). Methods: Clinical microinvasion and invasive implants, received FPS and died of disease.

FOCUS ON: OBJECTIVE. Borderline ovarian tumors comprise a unique group of noninvasive ovarian tumors with stromal microinvasion: a report of 21 cases.

carcinoma, microinvasion, invasive carcinoma) in huge mucinous tumor [ 12 ].

2002 ; 26 : 1111 –28. 5. Lethal recurrence data for micropapillary patterns (MPs), microinvasion, non‐invasive and invasive implants, and intraepithelial carcinoma (IECA). The primary measure of effect was the odds ratio of lethal recurrence reduction. Results. Data from patients in 42 studies including 4414 sBOTs and 12 studies including 894 mBOTs were pooled.
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All 3 patients with an aggressive disease course and poor outcome had increasing CA 125 levels at the time of recurrence. Comments: Borderline clear cell adenofibroma with a 2mm focus of microinvasion in a 10 cm tumor. The remainder of the tumor was composed entirely of benign areas. Clear cytoplasm and cytologic atypia are evident in the small nests.The larger dilated glands are lined by flattened epithelium lacking atypia.

Thus, the identification of stromal  1 Oct 2017 14.3% of patients had microinvasive disease and 14.3 % had micro papillary disease on histopathology. 9 patients (16.1 %) had peritoneal. patients with serous borderline ovarian tumor (BOT).
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Mucinous tumors of the ovary are a continuing source of controversy in the field of gynecologic pathology. We examined a series of 171 intestinal-type mucinous tumors of low malignant potential (“borderline” or “atypical proliferative” tumors) to clarify the clinical significance of intraepithelial carcinoma (IECA) and microinvasion (area ≤10 mm 2).

A 39-year-old female presented with abdominal distension. A right adnexal mass was found on physical examination, which was shown to be cystic on ultrasound. An exploratory laparotomy revealed a right ovarian mass, which was removed and a staging procedure was performed. Histologically, the mass was a borderline ovarian tumor with stromal microinvasion and hemangiomatous mural nodules. Se hela listan på emedicine.medscape.com Mucinous borderline tumor Microinvasion • No single invasive focus should measure >5 mm or 10 mm2 • Multiple foci can occur • Prognosis similar to borderline tumors (one recent study shows higher risk of recurrence) Microscopic: Mucinous borderline tumor with microinvasion Mucinous borderline tumor with microinvasion Borderline ovarian tumor. Borderline ovarian tumours differ from epithelial ovarian cancer by their low incidence, frequent association with infertility, low association with mutations in BCRA genes, different percentages of the most common histological types, early stage diagnosis, and high survival rate, even when associated with peritoneal involvement. A. W. Kennedy and W. R. Hart, “Ovarian papillary serous tumors of low malignant potential (serous borderline tumors): a long term follow up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma,” Cancer, vol.

is important in difficult cases, particularly in borderline tumors of the ovary. The upper size limitfor microinvasion has been arbitrarily set at 10 mm2 (10).

Borderline ovarian tumours differ from epithelial ovarian cancer by their low incidence, frequent association with infertility, low association with mutations in BCRA genes, different percentages of the most common histological types, early stage diagnosis, and high survival rate, even when associated with peritoneal involvement. Microinvasion is reported in up to nine per cent of mucinous borderline tumours of intestinal-type.1 Invasive foci may consist of single cells, small clusters, glands or foci of confluent or cribriform growth within the stroma (see Figure 6). Borderline is usually treated with surgery and followup. The chance of recurrence is minimal. I would ask the doctor to explain exactly what is meant by microinvasion, what type of follow up he suggests, if he has had experience with other borderline patients and how they have progressed. Borderline tumors account for 14 to 15 percent of all primary ovarian neoplasms .

Serous borderline tumors (SBTs) account for one-fourth to one-third of the non-benign serous tumors. 26,27 They are most common in the fourth and fifth decades, with an average patient age of 42 years.